Dr Kedikilwe is the Chairman of Sefalana Holding Company Limited. He brings a wealth of experience to Sefalana having served in various positions in his illustrious career. This includes being Vice President of Botswana, Minister of Minerals, Energy and Water Resources, Minister of Education, Minister of Finance and Development Planning, Minister of Trade and Industry, Minister of Presidential Affairs and Public Administration, Assistant Minister of Finance and Development Planning, and Member of Parliament for the Mmadinare Constituency from 1984-2014.
Dr Kedikilwe held various leadership positions including; Board member of Botswana Diamond Valuing Company and Bank of Botswana, Member of the Monetary Preparatory Commission that recommended the establishment of the Bank of Botswana and the introduction of the Pula currency in 1975/76, Alternate Governor for the International Monetary Fund, founding Board Member of the Botswana Housing Corporation, Board member of the Botswana Power Corporation, Chairman of Presidential Commission on Education, Chairman of Council at the University of Botswana, Chairman of the Central Tender Board, (now PPADB), Permanent Secretary of Works and Communications Ministry, Director of Public Service Management and Director of Financial Affairs in the Ministry of Finance and Development Planning.
During his career, Dr Kedikilwe received the Presidential Order of Honour for Distinguished Public Service in 1992, Grand Cordon of the Order of the Rising Sun, awarded by the Emperor of Japan in 2011 and Naledi Ya Botswana in 2014. In March 2016 he was appointed Chairman of the Presidential Inspectorate Task Team. He was appointed Vice Chancellor of the Botswana Open University in March 2018.